Each stock option vests over the course of four years, with 25% vesting on the one-year anniversary of the grant date and 1/48 of the shares vesting monthly thereafter so that all of the shares subject to the stock option shall be vested on the fourth anniversary of the grant date, subject to the new employee’s continued service relationship with the Company on each such date. Each stock option has a ten-year term and is subject to the terms and conditions of the Company’s 2007 Equity Incentive Award Plan and the stock option agreement pursuant to which the option is granted. The stock options were granted as an inducement material to Eastland’s and the other new employees’ entering into employment with Orexigen Therapeutics in accordance with NASDAQ Listing Rule 5635(c)(4). About CONTRAVE CONTRAVE, approved by the United States Food and Drug Administration in September 2014, is indicated for use as an adjunct to a reduced-calorie diet and increased physical activity for chronic weight management in adults with an initial body mass index (BMI) of 30 kg/m2 or greater (obese), or 27 kg/m2 or greater (overweight) in the presence of at least one weight-related comorbid condition (e.g., hypertension, type 2 diabetes mellitus or dyslipidemia). The exact neurochemical effects of CONTRAVE leading to weight loss are not fully understood. CONTRAVE has two components: naltrexone, an opioid antagonist, and bupropion, a relatively weak inhibitor of the neuronal reuptake of dopamine and norepinephrine. Nonclinical studies suggest that naltrexone and bupropion have effects on two separate areas of the brain involved in the regulation of food intake: the hypothalamus (appetite regulatory center) and the mesolimbic dopamine circuit (reward system). Four 56-week multicenter, double-blind, placebo-controlled Phase 3 clinical trials were conducted to evaluate the effect of CONTRAVE in conjunction with lifestyle modification in 4,536 subjects randomized to CONTRAVE or placebo. In these studies, the most common adverse reactions (>5 percent) seen in patients taking CONTRAVE included nausea, constipation, headache, vomiting, dizziness, insomnia, dry mouth, and diarrhea. Important Safety Information WARNING: SUICIDAL THOUGHTS AND BEHAVIORS; AND NEUROPSYCHIATRIC REACTIONS Suicidality and Antidepressant Drugs CONTRAVE is not approved for use in the treatment of major depressive disorder or other psychiatric disorders. CONTRAVE contains bupropion, the same active ingredient as some other antidepressant medications (including, but not limited to, WELLBUTRIN, WELLBUTRIN SR, WELLBUTRIN XL, and APLENZIN).
For the original version including any supplementary images or video, visit Orexigen Therapeutics Expands Commercial Capabilities with Appointment of Beth Eastland, Vice President of Sales, and Eight Additional New Employees – Yahoo Finance
Brenner CC. The binging and purging cycle usually repeats several times a week. Many of the chat rooms are short-lived. Regular maintenance of healthy eating patterns and thought processes in those who are recovering from eating disorders must continue long after the initial medical and psychological crisis has receded. Therapy for a person with bulimia may be one-on-one with a therapist or group-based. Weinstein, J.J. and P.S. This behaviour can take two forms: self-induced vomiting, misuse of enemas, laxatives, diet pills called purging and excessive exercise, fasting, or diabetic omission of insulin called non-purging. Omega-3 fatty acids, such as fish oil, 1 to 2 capsules or 1 tablespoonful oil, 2 to 3 times daily, to help reduce inflammation, boost immunity, and improve mood.
Patients with eating disorders generally receive a combination of medical care and psychiatric treatment. Resist urges to weigh yourself or check yourself in the mirror frequently. Ensure you get regular exercise, walking once a day is good. Initial evaluation, diagnosis, and treatment of anorexia nervosa and bulimia nervosa. It is important that whatever treatment they have that the reasons behind the eating disorder are addressed, not just the eating disorder itself, otherwise, it is highly likely that the eating disorder will return. Everyone differs from another, and taking such a complex behaviour like bulimia and applying the same one theory to everyone would certainly be invalid. Weight can also dramatically shift, and large swings might be an indicator that someone is developing an eating disorder. The National Association of Anorexia Nervosa and Associated Disorders Many people who suffer from bulimia also exhibit signs of anorexia nervosa. International Journal of Eating Disorders. 2013;46:3.